Fructose-Induced Hyperuricemia Is Associated With a Decreased Renal Uric Acid Excretion in Humans. Virgile Lecoultre, PHD1,; Léonie Egli, MSC1,; Fanny. Fructose-induced hyperuricemia and hyperuricaciduria is associated with a striking increase in the blood lactate concentration, a decrease in erythrocyte. As such, we propose that the epidemic of the metabolic syndrome is due in part to fructose-induced hyperuricemia that reduces endothelial NO levels and.
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Although the cumulative fructose load was large 1.
The lack of hyperruricemia in galactosemia patients after galactose ingestion may be explained by the observation that galactose is phosphorylated more slowly than fructose.
Fructose–unlike other sugars–causes serum uric acid levels to rise rapidly. It has not been assessed, however, whether UA also increases when fructose is hyperuridemia as several small drinks instead of one single large load or whether a high-fructose diet HFrD impairs renal UA clearance UAC or fractional excretion UAFE as observed in rats 3.
The mean blood inorganic phosphate Pi levels were significantly less than the mean fasting value after fructose.
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Fructose-induced hyperuricemia results in endothelial dysfunction and insulin resistance, and might be a novel causal mechanism of the metabolic syndrome. Am J Physiol Renal Physiol ; In two patients with hereditary fructose intolerance HFI the peak blood uric acid levels were Consistent with this hypothesis is the observation that changes in mean uric acid levels correlate with the increasing prevalence of metabolic syndrome in the US and developing countries. This effect appears to be specific for fructose.
The serum Pi levels decreased less in galactosemic patients after galactose administration than in patients with HFI after fructose infusion. As such, we propose that the epidemic of the metabolic syndrome is due in part to fructose-induced hyperuricemia that reduces endothelial NO levels and induces insulin resistance. These observations suggest that a decreased urinary UA excretion may contribute to fructose-induced hyperuricemia.
The increasing incidence of obesity and the metabolic syndrome over the past two decades has coincided with a marked increase in total fructose intake. Parts of this study were presented in abstract form at Experimental BiologyBoston, Massachusetts, 20—24 April Furthermore, high-fructose intake over several days is associated with increased fasting UA concentration 1. In addition, we observed that a serum uric acid level above 5.
Open in a separate window. Exercise prevents fructose-induced hypertriglyceridemia in healthy young subjects.
inducex In two patients with HFI the uric acid excretion increased four- to fivefold after fructose administration; the increased uric acid excretion in HFI exceeded that of normal children.
These effects are generally attributed to an increased UA production, as observed after intravenous fructose administration 2. This study was supported by grant from the Swiss National Foundation for Science and by a grant from Ajinomoto Co.
National Center for Biotechnology InformationU. After the infusion of hyperurcemia, 0. Nutr Metab Lond ; 9: The mean uric acid excretion, expressed as milligrams per mg urinary creatinine, was 0. Acknowledgments This study was supported by grant from the Swiss National Foundation for Science and by a grant from Ajinomoto Co.
Because the metabolic effects of fructose show significant sex differences, it remains to be assessed whether the same effects are observed in female subjects. Studies in humans should be performed to address whether lowering uric acid levels will help to prevent this condition.
These samples were collected while subjects were participating in two clinical trials clinical trial reg. Effects of supplementation with essential amino acids on intrahepatic lipid concentrations during fructose overfeeding in humans. Support Center Support Center. We recently reported that uric acid reduces levels of endothelial nitric oxide NOa key mediator of insulin action. NO increases blood flow to skeletal muscle and enhances glucose uptake.
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This article has been cited by other articles in PMC. Allopurinol, rutin, and quercetin attenuate hyperuricemia and renal dysfunction in rats induced by fructose intake: In three patients with galactosemia, increases in blood uric acid levels after galactose ingestion were similar to those in normal children after fructose, but less than those in patients with HFI after fructose.
Urinary UA excretion rate. This mechanism may substantially enhance the risk of gout in people who consume high amounts of sugar. Published online Aug Ingestion of a high-fructose meal increases blood uric acid UA concentration in healthy subjects 1.
These studies support the hypothesis that fructose-induced hyperuricemia results from degradation of adenosine monophosphate.
Fructose-Induced Hyperuricemia Is Associated With a Decreased Renal Uric Acid Excretion in Humans
Animals deficient in endothelial NO develop insulin resistance and other features of the metabolic syndrome. Journal List Diabetes Care v. Readers may use this article as long as the work is properly cited, the use is educational and not indhced profit, and the work is not altered.
Am J Clin Nutr ; No other potential conflicts of interest relevant to this article were reported. F—F [ PubMed ]. The serum Pi level decreased 2. Blood glucose, lactic acid, and fructose levels were significantly increased after fructose, but serum magnesium levels did not change. Closed symbols represent data collected after 4—6 days of HFrD.